A funded postdoctoral position for three years is available in the Division of Nephrology at RWTH Aachen University in Aachen, Germany.
The Kramann laboratory (http://www.kramannlab.com) studies the cellular and molecular mechanisms of organ fibrosis (heart, kindey, bone marrow and lung). We have recently identified pericyte progenitor cells as a major source of organ fibrosis (Kramann et al. Cell Stem Cell 2015). We are now exploring these cells in mice and human with the goal to develop novel targeted therapeutics for the vast and growing patient population with organ fibrosis. It is estimated that fibrosis is responsible for almost 50% of all deaths in the developed world.
This postdoctoral project will focus on target identification using RNA-Seq and proteomics from human and mouse followed by in vitro and in vivo target validation experiments using CRISPR/Cas9 assays. The ideal candidate will have outstanding molecular and cell biology training (cloning). Experience with mouse models and flow-cytometry is strongly preferred but not mandatory.
Training in a variety of mouse models or organ fibrosis will be provided. Furthermore, training for flow-cytometry, RNA-Seq, high resolution confocal-microscopy and CRISPR/Cas9 gene editing will be provided.
The position should appeal most scientists who want to perform cutting edge translational research with target identification, in vitro and in vivo gene editing and the ultimate goal to develop novel therapeutics with an impact on patients.
If you are interested in joining our team please contact Dr. Kramann by mailing your CV and letter of intent (rkramann@gmx.net).